

Vital Oncogenes
Vital Oncogenes are unlike the much touted typical oncogenes routinely targeted by pharmaceutical companies. ONCOSTEM's Bioinformatic analyses reveals these to be non-protein kinase entities with distinct and unique characteristics - described below.
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ONCOSTEM BIOTHERAPEUTICS has identified over 600 targets of interest. Each has some or all of the required Vital Oncogene characteristics. Approximately 100 fulfill stringent criteria. Approximately 75 fulfill stringent criteria and have significant evidenced-based supportive literature.
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Vital Oncogenes are mutated, fused gene regulators with all of the properties that distinctly indicate their capacity to initiate and propagate oncogenesis. This makes them the ideal candidates for potent, less toxic, uniquely specific targeted cancer therapy.
Oncogenic Characteristics
IT IS A MULTI-DOMAIN PHOSPHOPROTEIN TRANSCRIPTION ACTIVATOR
IT IS AN INTRINSICALLY DISORDERED PROTEIN
IT HAS A CHARACTERISTIC ACTIVATING MUTATION (FUSED PROTEIN)
IT HAS A DEMONSTRATED CANCER ASSOCIATION
ITS MOLECULAR MECHANISM OCCURS DIRECTLY WITHIN THE NUCLEUS
ITS ONCOPROTEIN PRODUCT IS FUNCTIONALLY UPSTREAM FROM ITS ASSOCIATED CELLULAR PATHWAYS
ITS ONCOPROTEIN PRODUCT MUST USURP OR ALTER NORMAL CELL CYCLE CONTROL MECHANISMS
THERE MUST BE CLINICAL EVIDENCE OF ONCOGENE ADDICTION
IT IS PROMOTER PROMISCUOUS
IT FUNCTIONS BY PROTEIN-PROTEIN INTERACTIONS
THERE IS A CRUCIAL COMMON MECHANISTIC EVENT INVOLVING ITS PROTEIN-PROTEIN INTERACTION.