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Vital Oncogenes

Vital Oncogenes are unlike the much touted typical oncogenes routinely targeted by pharmaceutical companies. ONCOSTEM's Bioinformatic analyses reveals these to be non-protein kinase entities with distinct and unique characteristics - described below.

ONCOSTEM BIOTHERAPEUTICS has identified over 600 targets of interest. Each has some or all of the required Vital Oncogene characteristics. Approximately 100 fulfill stringent criteria. Approximately 75 fulfill stringent criteria and have significant evidenced-based supportive literature.

Vital Oncogenes are mutated, fused gene regulators with all of the properties that distinctly indicate their capacity to initiate and propagate oncogenesis. This makes them the ideal candidates for potent, less toxic, uniquely specific targeted cancer therapy.

Science: Text

Oncogenic Characteristics

  • IT IS A  MULTI-DOMAIN PHOSPHOPROTEIN TRANSCRIPTION ACTIVATOR

  • IT IS AN INTRINSICALLY DISORDERED PROTEIN

  • IT HAS A CHARACTERISTIC ACTIVATING MUTATION (FUSED PROTEIN)

  • IT HAS A DEMONSTRATED CANCER ASSOCIATION

  • ITS MOLECULAR MECHANISM OCCURS DIRECTLY WITHIN THE NUCLEUS

  • ITS ONCOPROTEIN PRODUCT IS FUNCTIONALLY UPSTREAM FROM ITS ASSOCIATED CELLULAR PATHWAYS

  • ITS ONCOPROTEIN PRODUCT MUST USURP OR ALTER NORMAL CELL CYCLE CONTROL MECHANISMS

  • THERE MUST BE CLINICAL EVIDENCE OF ONCOGENE ADDICTION

  • IT IS PROMOTER PROMISCUOUS

  • IT FUNCTIONS BY PROTEIN-PROTEIN INTERACTIONS

  • THERE IS A CRUCIAL COMMON MECHANISTIC EVENT INVOLVING ITS PROTEIN-PROTEIN INTERACTION.

Science: Text

Willis RE. Targeted Cancer Therapy: Vital Oncogenes and a New Molecular Genetic Paradigm for Cancer Initiation Progression and Treatment. International Journal of Molecular Sciences. 2016; 17(9):1552. https://doi.org/10.3390/ijms17091552

Willis RE. Human Gene Control by Vital Oncogenes: Revisiting a Theoretical Model and Its Implications for Targeted Cancer Therapy. International Journal of Molecular Sciences. 2012; 13(1):316-335. https://doi.org/10.3390/ijms13010316

Panicker S, Venkatabalasubramanian S, Pathak S, Ramalingam S. The impact of fusion genes on cancer stem cells and drug resistance. Mol Cell Biochem. 2021 Oct;476(10):3771-3783. doi: 10.1007/s11010-021-04203-4. Epub 2021 Jun 7. PMID: 34095988.

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